Chamber of Commerce members are employers who all share on common ongoing needs core to their business success: attracting, recruiting, hiring, training, and upskilling workers. This Guide outlines the core components of Registered Apprenticeship, explains its benefits for chambers and member businesses, and provides actionable strategies for chambers to become active facilitators in their regions. It includes real-world case studies from Chambers across the country—including the Charleston, South Carolina Metro Chamber of Commerce, the Greater Cleveland Partnership, the Kentucky Chamber Foundation, and the German American Chamber of Commerce—to highlight successful approaches and scalable practices. The document concludes with practical next steps to help Chambers assess their members’ workforce development needs, align with apprenticeship systems, and create strategic partnerships that maximize impact. Through these efforts, Chambers can expand their role as vital workforce development leaders.